Polyphosphate kinase 1 of Burkholderia pseudomallei controls quorum sensing, RpoS and host cell invasion

Patompon Wongtrakoongate

Kitima Srisanga, Praewa Suthapot, Permkun Permsirivisarn, Piyarat Govitrapong, Sumalee Tungpradabkul, Patompon Wongtrakoongate      Burkholderia pseudomallei is a Gram negative bacterium and the causative agent of melioidosis. Nonetheless, how virulence factors and pathogenic mechanisms are regulated have been elusive. In this study, Read More …

A truncated del p53 variant identified in a cholangiocarcinoma cell line promotes cancer cell migration and invasiveness

     TP53, a tumor suppressor gene, is the most common gene mutated in human cancers, including in cholangiocarcinoma (CCA). Besides loss of tumor suppressive function, some mutant p53 possess the gain-of-function properties promoting cancer progression. Here we demonstrated for the first Read More …

Overexpression of Holocarboxylase Synthetase Predicts Lymph Node Metastasis and Unfavorable Prognosis in Breast Cancer

Sarawut Jitrapakdee

Overexpression of Holocarboxylase Synthetase Predicts Lymph Node Metastasis and Unfavorable Prognosis in Breast Cancer Witchuda Sukjoi1, Siraprapa Siritutsoontorn1, Pakkanan Chansongkrow1, Suppakit Waiwitlikhit1,2, Steven W. Polyak3, Malee Warnnissorn4, Varodom Charoensawan1,5,6,Chanitra Thuwajit7, Sarawut Jitrapakdee1* 1Department of Biochemistry, Faculty of Science, Mahidol University, Read More …

Characterization of intra- and inter-species hybrid tetramers of pyruvate carboxylase: Biotin and the BCCP domain play a crucial role in determination of the kinetics and thermodynamics of catalysis

Sarawut Jitrapakdee

Characterization of intra- and inter-species hybrid tetramers of pyruvate carboxylase: Biotin and the BCCP domain play a crucial role in determination of the kinetics and thermodynamics of catalysis Khanti Rattanapornsompong, Sarawut Jitrapakdee1 and Paul V. Attwood2 1Department of Biochemistry, Faculty Read More …