SRPK Inhibitors Reduce the Phosphorylation and Translocation of SR Protein Splicing Factors, thereby Correcting BIN1, MCL-1 and BCL2 Splicing Errors and Enabling Apoptosis of Cholangiocarcinoma Cells
Cholangiocarcinoma (CCA), a common bile duct cancer in Thailand, has poor survival rates due to limited diagnostic and treatment options ...
Identification and preclinical evaluation of MMV676558 as a promising therapeutic candidate against Clostridioides difficile
Clostridioides difficile is a bacterium that causes severe diarrhea, especially after antibiotic use. Current treatments, like fidaxomicin and vancomycin, work ...
Quantum dots as a fluorescent labeling tool for live-cell imaging of Leptospira.
In this study, cadmium telluride quantum dots (CdTe QDs) was synthesized and modified surface with concanavalin A (ConA), a carbohydrate-binding ...
Antioxidant and antimicrobial activities of mango peel and radish peel-a comparative investigation
The study explored the antioxidant and antimicrobial properties of ethanolic extracts from Bao Mango and Thai daikon radish peels ...
Anti-cancer Activity of Ethanolic Extract from ‘Bao’ mango (Mangifera indica) Peel and Its Nanoencapsulation Against Triple-Negative Breast Cancer Cell Lines
This work, 'Bao' mango peel extract (MPE) was investigated for its antioxidant and anti-cancer activities. Furthermore, after encapsulation with ...
The complete catalog of antimicrobial resistance secondary active transporters in Clostridioides difficile: evolution and drug resistance perspective
Secondary active transporters move substances across cell membranes in both eukaryotic and prokaryotic organisms, using different ...
Development of Carbon Dots Synthesized from Green Tea and Alpha-Hydroxyl Acids with Enhanced Antioxidant Activity, Photostability and UV Protection Properties
The exhaustion of the ozone layer in the atmosphere has increased UV radiation penetrating the earth’s surface, leading to severe ...
Preparation of Decellularized Tissue as Dual Cell Carrier Systems: A Step Towards Facilitating Re-epithelization and Cell Encapsulation for Tracheal Reconstruction
Tissue-based treatments, involving the cultivation of patient cells on a network of extracellular matrix (ECM) from donor tissue, hold promise ...
BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
The precise etiology of breast cancer is not completely understood, although women with inherited BRCA1 gene ...
Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Ursolic Acid for Breast Cancer Therapy
This work, we used chitosan-coated poly(lactic-co-glycolic acid) (PLGA/CS) nanoparticles to encapsulate ursolic acid (UA). UA is a pentacyclic triterpenoid ...