Highlights

Rutaiwan Tohtong

Molecularly Guided Drug Repurposing for Cholangiocarcinoma: An Integrative Bioinformatic Approach

Cholangiocarcinoma (CCA) has a complex immune microenvironment architecture, thus possessing challenges in its characterization and treatment. This study aimed to ...
Read More
Rutaiwan Tohtong

In Silico Target Identification of Galangin, as an Herbal Flavonoid against Cholangiocarcinoma

Cholangiocarcinoma (CCA) is a heterogenous group of malignancies in the bile duct which proliferates aggressively. As a result, most patients ...
Read More
Sakonwan Kuhaudomlarp

Druggable Allosteric Sites in β-Propeller Lectins

β-Propeller lectins are a group of carbohydrate binding proteins consisting of repetitive protomers arranged in a propeller configuration. These lectins ...
Read More
Sakonwan Kuhaudomlarp

Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA

LecA is a carbohydrate-binding protein released by an opportunistic bacterium Pseudomonas aeruginosa, as part of a myriad of virulence factors ...
Read More
Sakonwan Kuhaudomlarp

Targeting undruggable carbohydrate recognition sites through focused fragment library design

Carbohydrate binding proteins are therapeutic targets because of their key role in host-pathogen recognition and cell-to-cell communication. Unfortunately, the hydrophilic ...
Read More
Varodom Charoensawan

PGE 2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

In collaboration with Dr. Dean Thumkeo and his team, Charoensawan laboratory at Department of Biochemistry, Faculty of Science, has contributed ...
Read More
Patompon Wongtrakoongate

The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2

Understanding human neurogenesis is critical toward regenerative medicine for neurodegeneration. However, little is known how neural differentiation is regulated by ...
Read More
Patompon Wongtrakoongate

A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera

        Next-generation COVID-19 vaccines are critical due to the ongoing evolution of SARS-CoV-2 virus and rapid waning duration of the neutralizing ...
Read More
Tavan Janvilisri

Comparative Proteomic Profiling of Cisplatin-resistant Nasopharyngeal Carcinoma Cell Lines: Novel Biomarkers for Improving Chemotherapy of NPC

       Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the ...
Read More