Cancer and Stem Cell Biology


     Cancer is fundamentally a genetic disease that causes problems globally and locally. Cancer is caused by a massive growth of cells undergoing accumulation of genetic alterations as well as disruption of DNA modification, resulting in deregulation of cell proliferation, differentiation, survival and apoptosis. Besides deregulation of cell proliferation, cancer has also ability to invadeand metastasize to the distant site of the body. The research projects ongoing in our group aim to identify the molecular mechanisms and signaling processes underlying two types of cancers that are widely found in Thai population , cholangiocarcinoma and cervical cancers. Cholangiocarcinoma is known to be associated with liver flukes whereas cervical cancer is known to be caused by human papillomaviruses. The roles of these pathogens in interfering with human immune response are our special interests.
The specific projects ongoing within this group are
1. Molecular mechanism of cholangiocarcinoma cell proliferation and invasion in response to extracellular signals such as inflammatory cytokines, growth factors, and liver fluke products
(Assoc. Prof. Rutaiwan Tohtong)
(Dr. Waraporn Komyod)
(Assoc. Prof. Tuangporn Suthiphongchai)
(Assoc. Prof. Tavan Janvilisri)
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2. Pathogenesis of nasopharyngeal carcinoma
(Assoc. Prof. Tavan Janvilisri)
3. Angiogenesis and Metastasis
(Asst. Prof. Thaned Kangsamaksin)