Nanoencapsulation of vitamin B2 using chitosan-modified PLGA nanoparticles: synthesis, characterization, and in vitro studies on simulated gastrointestinal stability and delivery

     Vitamin B2 (riboflavin) is important for keeping our cells healthy, but it breaks down easily in light, does not dissolve well in water, and is hard for the body to absorb. This study used nanoparticles made from PLGA and coated with chitosan (CS-PLGA NPs) to protect and deliver vitamin B2 more effectively. These nanoparticles were very small (under 200 nanometers), stable, and helped vitamin B2 stay intact under UV light and in body-like fluids. They also released the vitamin slowly and were better absorbed by gut cells in lab tests. Overall, this delivery system could be useful for adding vitamin B2 to food, supplements, or medicines.