Poly(lactic-co-glycolic acid) Microspheres Encapsulating a Viral-Binding Protein, PmRab7, for Preventing White Spot Syndrome Virus (WSSV) in Shrimp.

        White spot syndrome virus (WSSV) is a severe disease that rapidly kills shrimp, resulting in significant economic losses for shrimp farmers. A shrimp protein called PmRab7 can help stop the virus, but it needs an effective way to be delivered through shrimp feed.

        In this study, researchers developed delivery systems using a safe, biodegradable material called PLGA, and coated with chitosan (PLGA/CS). These microspheres can carry PmRab7 and release it slowly over time. The study on shrimp showed that these microspheres are safe and help reduce shrimp deaths from WSSV. This new delivery method offers a promising way to better protect shrimp from deadly viral infections, supporting healthier shrimp farming and reducing economic losses.