Proteomic analysis reveals distinct protein corona compositions of citrate- and riboflavin- coated SPIONs

        This work, we reported the protein corona analysis of citrate- and riboflavin- coated superpartamagnetic iron oxide nanoparticles. Both are widely used as surface coating and ligands for enhancing cellular uptake in breast cancer cells. We have shown that even though both types of particles have similar sizes and zeta potentials, but they showed distinct protein corona fingerprints which also impact to in vitro study in MCF-cells. We also demonstrated that with the appropriate formation of protein corona, it promoted the higher cellular uptake of the riboflavin coated SPIONs in breast cancer cells. Our study of protein corona fingerprints in this work provides essential information for further development of strategy to reduce or stimulate immune response in vivo to increase therapeutic applications.

Reference

Mekseriwattana W, Thiangtrongjit T, Reamtong O, Wongtrakoongate P, Katewongsa KP. Proteomic Analysis Reveals Distinct Protein Corona Compositions of Citrate- and Riboflavin-Coated SPIONs. ACS Omega. 2022 Oct 12;7(42):37589-37599.

DOI: 10.1021/acsomega.2c04440