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In this study, cadmium telluride quantum dots (CdTe QDs) was synthesized and modified surface with concanavalin A (ConA), a carbohydrate-binding lectin and known biological probe for Gram-negative bacteria to obtain ConA-QDs. The QDs can effectively bind on Leptospira and exhibit strong fluorescence under simple fluorescence microscopy, allowing the live-cell imaging of the bacteria. This technique could be further applied to track leptospiral cells and study the infection mechanism, contributing to a more thorough understanding of leptospirosis and how to control it in the future.
Reference
Tantiapibalkun Y, Nuchpun S, Mekseriwattana W, Limsampan S, Douangchawee G, Jangpatarapongsa K, Srikhirin T, Katewongsa KP. Quantum dots as a fluorescent labeling tool for live-cell imaging of Leptospira.The article is now published on Nanoscale. Nanoscale, 2024.
DOI: 10.1039/D4NR00543K.
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