Teicoplanin Suppresses Vegetative Clostridioides difficile and Spore Outgrowth

        Clostridioides difficile, previously known as Clostridium difficile, infection (CDI) accounts for about 20–25% of antibiotic associated diarrhea. It is classified as a pathogen posing an urgent threat due to antibiotic resistance. Treatment for CDI is now limited to a few antibiotics, hence new antibiotics for CDI are of utmost importance. Here we investigated the effect of teicoplanin, a mixture of glycopeptide antibiotics, on spore germination and outgrowth in C. difficile isolates from different host origins and compared it to its vancomycin counterpart. Our results indicated that teicoplanin could be a potential therapeutic drug for C. difficile due to its potent activity at low concentrations, as well as having pre-determined broad-spectrum activity against gram-positive anaerobes.

Reference:

Ojha SC, Phanchana M, Harnvoravongchai P, Chankhamhaengdecha S, Singhakaew S, Ounjai P, Janvilisri T. Teicoplanin Suppresses Vegetative Clostridioides difficile and Spore Outgrowth. Antibiotics (Basel). 2021 Aug 15;10(8):984. doi: 10.3390/antibiotics10080984. PMID: 34439034; PMCID: PMC8388965.

DOI: 10.3390/antibiotics10080984