The repertoire of ABC proteins in Clostridioides difficile

        Many ABC proteins are involved in the transport of substrates across biological membranes. Bacterial ABC systems promote the ability to survive in various environments and are major factors conferring antibiotic resistance. Identification of ABC systems associated with drug resistance in other organisms has provided a better understanding of the function and mechanism of these bacterial proteins. Here, we classified and constructed ABC systems based on their substrates. We also analyzed and identified core and accessory ABC proteins in the gram-positive bacterium Clostridioides difficile. Our data present an overview of the C. difficile ABC proteins and should aid in the design of experimental investigations toward a better understanding of the functional and evolutionary relationships among these transporters.

Reference:

Pipatthana M, Harnvoravongchai P, Pongchaikul P, Likhitrattanapisal S, Phanchana M, Chankhamhaengdecha S, Janvilisri T. The repertoire of ABC proteins in Clostridioides difficile. Comput Struct Biotechnol J. 2021 May 8; 19:2905-2920. doi: 10.1016/j.csbj.2021.05.012. PMID: 34094001; PMCID: PMC8144104.

DOI: 10.1016/j.csbj.2021.05.012