Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration

Kornkamon Lertsuwan

       The endocannabinoid system has been postulated to help restrict cancer progression and maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid receptor (CB) type 1 and 2 activation on breast cancer cell and osteoblast interaction were investigated by Read More …

Single-cell temporal analysis of natural dengue infection reveals skin-homing lymphocyte expansion one day before defervescence

Varodom Charoensawan

          Dr. Charoensawan and his team have analyzed single-cell transcriptomic profiles of the peripheral blood mononuclear cell samples from two DENV patients, collected daily during acute phase and also at convalescence, and demonstrated different dynamic responses over the course of the infection. On Read More …

Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts

Varodom Charoensawan

  Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts In collaboration with Dr Chalermchai Mitrpant, Charoensawan laboratory at Department of Biochemistry, Faculty of Science, has contributed to the transcriptomic analyses showing that splice Read More …

The role of the phosphate groups of trinitrophenyl adenosine 5′-triphosphate (TNP-ATP) in allosteric activation of pyruvate carboxylase and the inhibition of acetyl CoA-dependent activation

Sarawut Jitrapakdee

          Pyruvate carboxylase (PC) (EC 6.4.1.1) is a biotin-dependent carboxylase which catalyzes the ATP-dependent carboxylation of pyruvate to form oxaloacetate which is an important precursor for several metabolic pathways including gluconeogenesis, lipogenesis, neurotransmitter synthesis and glucose-induced insulin secretion from pancreatic Read More …