D-Luciferin (D-LH2) is the most widely used substrate for beetle luciferases in bioluminescence applications. Here, we synthesized six D-LH₂ analogues, including the novel 5’,7’-dimethoxy-D-LH₂ and
Category: BC Research
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Riboflavin-PLGA nanoparticles enhance the effectiveness of the pyruvate carboxylase inhibitor ZY-444 in targeting lipogenesis in colon and breast cancer
New research highlights a powerful way to block aggressive colon and breast cancers by cutting off the energy and fats they need to grow. The
The cyclic peptide mallotumide A inhibits colon and breast cancer cell growth and motility by targeting cellular respiration and lipogenesis
Mallotumide A, a natural compound derived from plant roots, has shown high effectiveness in halting the spread and growth of aggressive colon and breast cancer
Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration
This research reveals that Erianin, a natural compound found in orchids, can effectively prevent the formation of new fat cells without being toxic to the
Discovery and biochemical characterization of enzymes completing the 4-hydroxyphenylacetate pathway in Acinetobacter baumannii TH
The 4-hydroxyphenylacetate (4-HPA) degradation pathway enables environmental and pathogenic microbes to assimilate aromatic compounds, yet several steps in Acinetobacter baumannii TH remain unclear. While enzymes
Structure and reaction mechanisms of a two-component indole monooxygenase from Acinetobacter baumannii
This study investigates how two-component indole monooxygenase from Acinetobacter baumannii converts indole into 3-hydroxyindole. The enzyme system consists of two cooperating proteins: reductase supplies reduced
Enhancing plant growth using anaerobic co-digestate of pig manure, food waste, and coffee grounds
This study demonstrates the use of anaerobic co-digestate liquid (AcoDL) derived from pig manure inoculum, food waste, and spent coffee grounds (PMI/FW/SCG) as a sustainable
Association of a CD44s-v5-v6 Null Phenotype with Advanced Stage Cholangiocarcinoma: A Preliminary Study
Cholangiocarcinoma is a very aggressive bile duct cancer with poor survival rates, making it crucial for doctors to better predict patient outcomes. Scientists have long
Kinetic analysis of catalytic activity of G-quadruplex/hemin DNAzyme with flanking adenine nucleotides
This study shows that adding adenine (A) bases to the 3′ end of a G-quadruplex/hemin DNAzyme greatly boosts its enzyme-like activity. The modified DNAzyme became
Biologics, Biosimilars, and Biobetters: Therapeutic Innovations Reshaping Modern Medicine
Biologic medicines are advanced drugs made from living cells. They are effective for treating cancer and other serious diseases, but they are very expensive to