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Category: BC Research

for Research Highlights only

Preclinical evidence for anaplastic lymphoma kinase inhibitors as novel therapeutic treatments for cholangiocarcinoma

Preclinical evidence for anaplastic lymphoma kinase inhibitors as novel therapeutic treatments for cholangiocarcinoma

Introduction: Bile duct cancer (cholangiocarcinoma, CCA) has a poor prognosis for patients, and despite recent advances in targeted therapies for other cancer types, it is still

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MicroRNA expression profiles associated with the metastatic ability of MDA‑MB‑231 breast cancer cells

MicroRNA expression profiles associated with the metastatic ability of MDA‑MB‑231 breast cancer cells

Breast cancer is an important worldwide public health concern and its incidence increases every year. MicroRNAs (miRs/miRNAs) are small non-coding RNAs that control gene expression

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Anti-Xanthine Oxidase 5′-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol

Anti-Xanthine Oxidase 5′-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol

Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this mushroom is an attractive source of natural products for cancer treatment, little is

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Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

Holocarboxylase synthetase (HLCS) is the enzyme that regulates biotin carboxylase activities, and plays an important role in cancer metabolism. Here, we investigated the global biochemical

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Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells

Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells

        Cholangiocarcinoma (CCA), a bile duct cancer, is an aggressive cancer with poor prognosis. It is typically recognized by its dense extracellular matrix nature which associated

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Proteomic Analysis and Molecular Dynamics Simulation of Riboflavin-Coated Superparamagnetic Iron Oxide Nanoparticles Reveal Human Serum-Derived Protein Coronas: Implications as Magnetic Resonance Imaging Contrast Agents

Proteomic Analysis and Molecular Dynamics Simulation of Riboflavin-Coated Superparamagnetic Iron Oxide Nanoparticles Reveal Human Serum-Derived Protein Coronas: Implications as Magnetic Resonance Imaging Contrast Agents

    This work, protein coronas of bare, citrate-coated, and Rf-coated SPIONs formed with human serum (HS) were studied by proteomic analysis to identify and quantify the

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Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase

Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase

          Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of meningococcal diseases. In this study,

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Mangiferin is a new potential antimalarial and anticancer drug for targeting serine hydroxymethyltransferase

Mangiferin is a new potential antimalarial and anticancer drug for targeting serine hydroxymethyltransferase

          Serine hydroxymethyltransferase (SHMT) is a key enzyme in the deoxythymidylate synthesis cycle, essential for pathogen proliferations, including malaria parasite. Therefore, SHMT is an attractive

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Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage

Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage

          Dimethyl sulfone monooxygenase catalyzes the oxidative cleavage of dimethyl sulfone (DMSO2) to produce methanesulfinate and formaldehyde. It is a two-component monooxygenase composed of a

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The plasmid vectors, pBS2ndd and pBS3ndd, for versatile cloning with low background in Escherichia coli

The plasmid vectors, pBS2ndd and pBS3ndd, for versatile cloning with low background in Escherichia coli

        This is another approach to reduce background colonies, or false positive clones that may be arisen from intact or self-ligated plasmid in molecular cloning. Two

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© 2024 Department of Biochemistry, Faculty of Science, Mahidol University
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