Cholangiocarcinoma (CCA) is a difficult-to-treat cancer, with limited therapeutic options and surgery being the only curative treatment. Standard chemotherapy involves gemcitabine-based therapies combined with cisplatin,
Category: BC Research
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Targeting MYC at the intersection between cancer metabolism and oncoimmunology
MYC activation is a known hallmark of cancer as it governs the gene targets involved in various facets of cancer progression. Of interest, MYC
In Silico and In Vitro Potential of FDA-Approved Drugs for Antimalarial Drug Repurposing against Plasmodium Serine Hydroxymethyltransferases
English Serine hydroxymethyltransferase (SHMT) is a key enzyme in deoxythymidylate synthesis pathway. It has been identified as a promising target for drug combating
Structure and biochemical characterization of an extradiol 3,4-dihydroxyphenylacetate 2,3-dioxygenase from Acinetobacter baumannii
English In this study, we report the structure and biochemical characterization of 3,4-Dihydroxyphenylacetate (DHPA) 2,3-dioxygenase (EC 1.13.11.15) from Acinetobacter baumannii (AbDHPAO), which is
A high catalytic efficiency and chemotolerant formate dehydrogenase from Bacillus simplex
English Formate dehydrogenase (FDH) catalyzes the reversible bioconversion of formate and NAD+ to produce carbon dioxide and NADH. FDH is biotechnologically important because it
Preclinical evidence for anaplastic lymphoma kinase inhibitors as novel therapeutic treatments for cholangiocarcinoma
Introduction: Bile duct cancer (cholangiocarcinoma, CCA) has a poor prognosis for patients, and despite recent advances in targeted therapies for other cancer types, it is still
MicroRNA expression profiles associated with the metastatic ability of MDA‑MB‑231 breast cancer cells
Breast cancer is an important worldwide public health concern and its incidence increases every year. MicroRNAs (miRs/miRNAs) are small non-coding RNAs that control gene expression
Anti-Xanthine Oxidase 5′-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol
Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this mushroom is an attractive source of natural products for cancer treatment, little is
Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism
Holocarboxylase synthetase (HLCS) is the enzyme that regulates biotin carboxylase activities, and plays an important role in cancer metabolism. Here, we investigated the global biochemical
Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells
Cholangiocarcinoma (CCA), a bile duct cancer, is an aggressive cancer with poor prognosis. It is typically recognized by its dense extracellular matrix nature which associated