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Category: BC Research

for Research Highlights only

Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

Holocarboxylase synthetase (HLCS) is the enzyme that regulates biotin carboxylase activities, and plays an important role in cancer metabolism. Here, we investigated the global biochemical

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Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells

Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells

        Cholangiocarcinoma (CCA), a bile duct cancer, is an aggressive cancer with poor prognosis. It is typically recognized by its dense extracellular matrix nature which associated

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Proteomic Analysis and Molecular Dynamics Simulation of Riboflavin-Coated Superparamagnetic Iron Oxide Nanoparticles Reveal Human Serum-Derived Protein Coronas: Implications as Magnetic Resonance Imaging Contrast Agents

Proteomic Analysis and Molecular Dynamics Simulation of Riboflavin-Coated Superparamagnetic Iron Oxide Nanoparticles Reveal Human Serum-Derived Protein Coronas: Implications as Magnetic Resonance Imaging Contrast Agents

    This work, protein coronas of bare, citrate-coated, and Rf-coated SPIONs formed with human serum (HS) were studied by proteomic analysis to identify and quantify the

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Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase

Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase

          Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of meningococcal diseases. In this study,

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Mangiferin is a new potential antimalarial and anticancer drug for targeting serine hydroxymethyltransferase

Mangiferin is a new potential antimalarial and anticancer drug for targeting serine hydroxymethyltransferase

          Serine hydroxymethyltransferase (SHMT) is a key enzyme in the deoxythymidylate synthesis cycle, essential for pathogen proliferations, including malaria parasite. Therefore, SHMT is an attractive

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Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage

Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage

          Dimethyl sulfone monooxygenase catalyzes the oxidative cleavage of dimethyl sulfone (DMSO2) to produce methanesulfinate and formaldehyde. It is a two-component monooxygenase composed of a

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The plasmid vectors, pBS2ndd and pBS3ndd, for versatile cloning with low background in Escherichia coli

The plasmid vectors, pBS2ndd and pBS3ndd, for versatile cloning with low background in Escherichia coli

        This is another approach to reduce background colonies, or false positive clones that may be arisen from intact or self-ligated plasmid in molecular cloning. Two

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Three novel mutations in α-galactosidase gene involving in galactomannan degradation in endosperm of curd coconut

Three novel mutations in α-galactosidase gene involving in galactomannan degradation in endosperm of curd coconut

        This is the first report to identify gene in coconut responsible for curd phenotype. The gene is endosperm specific α-galactosidase. DNA encoding α-galactosidase gene alleles

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Development and Validation of an Enzymatic Method to Determine Stevioside Content from Stevia rebaudiana

Development and Validation of an Enzymatic Method to Determine Stevioside Content from Stevia rebaudiana

        We established enzymatic method for specific determination of stevioside content. The key enzyme came from recombinant β-glucosidase BT_3567 (rBT_3567) from Bacteroides thetaiotaomicron HB-13 which exhibited

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Proteomic analysis reveals distinct protein corona compositions of citrate- and riboflavin- coated SPIONs

Proteomic analysis reveals distinct protein corona compositions of citrate- and riboflavin- coated SPIONs

        This work, we reported the protein corona analysis of citrate- and riboflavin- coated superpartamagnetic iron oxide nanoparticles. Both are widely used as surface coating and

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© 2024 Department of Biochemistry, Faculty of Science, Mahidol University
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