Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Ursolic Acid for Breast Cancer Therapy

  This work, we used chitosan-coated poly(lactic-co-glycolic acid) (PLGA/CS) nanoparticles to encapsulate ursolic acid (UA). UA is a pentacyclic triterpenoid found in various fruits and herbs and has potential as an anti-cancer agent against multiple cancer types. The NPs were successfully delivered into breast cancer cells (MCF-7 and MDA-MB-231) and enhanced the anti-cancer activity of UA. The improved cytotoxicity induced by (UA)-PLGA/CS NPs can be attributed to apoptosis induction, collective cell migration and invasion inhibition, and cell proliferation pathway disruption. These findings led to a better understanding of the anti-cancer effects and molecular mechanisms of the (UA)-PLGA/CS NPs and potential targets for breast cancer therapy.

Reference

Payomhom P, Panyain N, Sakonsinsiri C, Wongtrakoongate P, Lertsuwan K, Dakrong Pissuwan, and Katewongsa KP. Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Ursolic Acid for Breast Cancer Therapy. ACS Applied Nano Materials 2024 7 (5), 5383-5395.

DOI: 10.1021/acsanm.3c06161.