Dual Functions of Riboflavin-functionalized Poly(lactic-co-glycolic acid) Nanoparticles for Enhanced Drug Delivery Efficiency and Photodynamic Therapy in Triple-negative Breast Cancer Cells

        This work, we developed a novel drug delivery systems using riboflavin analogue to modify the surface of poly(lactic-co-glycolic acid) nanoparticles for target triple-negative breast cancer (TNBC) cells. This nanocarriers demonstrated ability to function as an effective anti-cancer drug delivery (doxorubicin) to TNBC cells. In addition, the riboflavin analogue plays a role as a photodynamic therapy agent to enhance phototoxicity of the cancer cells upon UV irradiation. Therefore, this work showed promising strategy to further develop in photodynamic therapy for breast cancer patients.

Reference:

Mekseriwattana, W., Phungsom, A., Sawasdee, K., Wongwienkham, P., Kuhakarn, C., Chaiyen, P. and Katewongsa, K.P. (2021), Dual Functions of Riboflavin-functionalized Poly(lactic-co-glycolic acid) Nanoparticles for Enhanced Drug Delivery Efficiency and Photodynamic Therapy in Triple-negative Breast Cancer Cells. Photochem Photobiol. https://doi.org/10.1111/php.13464

DOI: https://doi.org/10.1111/php.13464