Cholangiocarcinoma (CCA) is a heterogenous group of malignancies in the bile duct which proliferates aggressively. As a result, most patients are diagnosed in advanced stages, when the cancer has metastasized or severely progressed, thereby limiting treatment options. Several studies have investigated the potential effect of traditional Thai medicinal plants as therapeutic options in CCA treatment. In this study, we explored the potential of Galangin as a therapeutic drug for CCA treatment. Galangin is a herbal flavonoid found in Galangal, which is an important ingredient in cooking and in traditional medicine in many southeastern countries, We discovered that at high concentrations, Galangin killed the CCA cells, but at low concentrations, it did not kill the cells but suppressed the ability to move and to invade the tissues (an important part of the so-called, metastasis process). Additionally, we identified pathways and molecules that were affected by Galangin using proteomics and in silico analysis. Importantly, we highlighted c-Met as a candidate target, and suggest that Galangin can be a useful anti-metastatic therapeutic strategy in at least some subtypes of CCA patients.
Balasubramanian, B.; Venkatraman, S.; Myint, K.Z.; Krobthong, S.; Wongtrakoongate, P.; Sripa, J.; Rattanasinganchan, P.; Metheenukul, P.; Tohtong, R. In Silico Target Identification of Galangin, as an Herbal Flavonoid against Cholangiocarcinoma. Molecules 2022, 27, 4664.
|Prof. Rutaiwan Tohtong