Lectin affinity chromatography and quantitative proteomic analysis reveal that galectin-3 is associated with metastasis in nasopharyngeal carcinoma

     Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. Here we searched for potential glycoprotein biomarkers responsible for metastasis using proteomics. We showed, for the first time, that Galectin-3 plays a pivotal role in NPC metastasis. Galectin-3 could therefore be used for therapeutic intervention in NPC.

Reference:

Aimjongjun S, Reamtong O, Janvilisri T. Lectin affinity chromatography and quantitative proteomic analysis reveal that galectin-3 is associated with metastasis in nasopharyngeal carcinoma. Sci Rep. 2020 Oct 5;10(1):16462.