In collaboration with Dr. Dean Thumkeo and his team, Charoensawan laboratory at Department of Biochemistry, Faculty of Science, has contributed its expertise in single-cell transcriptomic analyses to the work that shows the PGE2-EP2/EP4 signaling functions as the key regulatory node linking active inflammation and immunosuppression in tumor microenvironment. The work serves as a potential platform for developing the EP2 and EP4 antagonists for cancer therapeutics.
(Image from https://doi.org/10.1016/j.celrep.2022.110914)
References
Thumkeo D, Punyawatthananukool S, Prasongtanakij S, Matsuura R, Arima K, Nie H, Yamamoto R, Aoyama N, Hamaguchi H, Sugahara S, Takeda S, Charoensawan V, Tanaka A, Sakaguchi S, Narumiya S. PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment. Cell Rep. 2022 Jun7;39(10):110914.
DOI:
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 Assoc. Prof. Varodom Charoensawan |