Reversal of cisplatin sensitization and abrogation of cisplatin-enriched cancer stem cells in 5-8F nasopharyngeal carcinoma cell line through a suppression of Wnt/β-catenin-signaling pathway

        Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. Here we showed that the cisplatin treatment enrichedcancer stem-like cells (CSCs), one major cause for failure of NPC chemotherapeutic treatments. The Wnt/β-catenin signaling is accountable for rising of the cancer stem-like cell population in NPC. Therefore, monitoring the targeted Wnt/β-catenin signaling pathway could potentially prevent the development of CSCs and improve the treatment efficiency in NPC.

Reference:

Sinnung S, Janvilisri T, Kiatwuthinon P. Reversal of cisplatin sensitization and abrogation of cisplatin-enriched cancer stem cells in 5-8F nasopharyngeal carcinoma cell line through a suppression of Wnt/β-catenin-signaling pathway. Mol Cell Biochem. 2021 Apr;476(4):1663-1672. doi: 10.1007/s11010-020-04045-6. Epub 2021 Jan 9. PMID: 33423190.

DOI: 10.1007/s11010-020-04045-6