This work, we developed a novel riboflavin (Rf) functionalized superparamagnetic iron oxide nanoparticles (SPIONs) that has been beneficial in the advancement of contrast agents and magnetic hyperthermia (MH) for the diagnosis and treatment of breast cancers. This Rf-SPIONs showed enhanced colloidal stability and high uptake potential in breast cancer cells. In addition, the overall characterization of the Rf-SPIONs both MRI and MH responses highlighted the excellent performance of this platform for theranostic applications in breast cancer.
Mekseriwattana W, Guardia P, Herrero BT, Fuente JMDL, Kuhakarn C, Roig A, Katewongsa KP. Riboflavin-citrate conjugate multicore SPIONs with enhanced magnetic responses and cellular uptake in breast cancer cells. Nanoscale Adv. 2022;4:1988-98.
|Asst. Prof. Kanlaya Katewongsa