Breast cancer is an important worldwide public health concern and its incidence increases every year. MicroRNAs (miRs/miRNAs) are small non-coding RNAs that control gene expression
Tag: SJ
Anti-Xanthine Oxidase 5′-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol
Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this mushroom is an attractive source of natural products for cancer treatment, little is
Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism
Holocarboxylase synthetase (HLCS) is the enzyme that regulates biotin carboxylase activities, and plays an important role in cancer metabolism. Here, we investigated the global biochemical
BC Faculty Seminar: January 10, 2024
BC Faculty Seminar “Development of smart nano-delivery platforms targeting colorectal cancer for personalized medicine: A showcase of ZY-444 small molecule targeting pyruvate carboxylase.” by Prof. Sarawut
The role of the phosphate groups of trinitrophenyl adenosine 5′-triphosphate (TNP-ATP) in allosteric activation of pyruvate carboxylase and the inhibition of acetyl CoA-dependent activation
Pyruvate carboxylase (PC) (EC 6.4.1.1) is a biotin-dependent carboxylase which catalyzes the ATP-dependent carboxylation of pyruvate to form oxaloacetate which is an important precursor
Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
The tricarboxylic acid (TCA) cycle functions as both an oxidative hub to oxidize acetyl-CoA and a biosynthetic hub for the synthesis of nucleotides,
Five-(Tetradecyloxy)-2-furoic Acid Alleviates Cholangiocarcinoma Growth by Inhibition of Cell-cycle Progression and Induction of Apoptosis
Metabolic reprograming in cancers is one of cancer hallmarks that allow cancer cell to expand and metastasize to other organs. In collaboration with Assoc Prof
Pyruvate carboxylase supports basal ATP-linked respiration in human pluripotent stem cell-derived brown adipocytes
Brown adipose tissue or BAT is the adipocytes that have a specific physiology in maintaining body temperature via thermogenesis. BAT activity is mainly
Differential growth inhibition, cell cycle arrest and apoptosis of MCF-7 and MDA-MB-231 cells to holocarboxylase synthetase suppression
Metabolic reprograming in cancers is one of cancer hallmarks that allow cancer cell to expand and metastasize to other organs. Professor Sarawut
BC Faculty Seminar: April 7, 2021
BC Faculty Seminar “Holocarboxylase synthetase as a novel anti-cancer target” by Prof. Sarawut Jitrapakdee Department of Biochemistry, Faculty of Science Mahidol University