Targeting MYC at the intersection between cancer metabolism and oncoimmunology

        MYC activation is a known hallmark of cancer as it governs the gene targets involved in various facets of cancer progression. Of interest, MYC governs oncometabolism through the interactions with its partners and cofactors, as well as cancer immunity via its gene targets. Recent investigations have taken interest in characterizing these interactions through multi-Omic approaches, to better understand the vastness of the MYC network. Of the several gene targets of MYC involved in either oncometabolism or oncoimmunology, few of them overlap in function. Prominent interactions have been observed with MYC and HIF-1a, in promoting glucose and glutamine metabolism and activation of antigen presentation on regulatory T cells, and its subsequent metabolic reprogramming. This review explores existing knowledge of the role of MYC in oncometabolism and oncoimmunology. It also unravels how MYC governs transcription and influences cellular metabolism to facilitate the induction of pro- or anti-tumoral immunity. Moreover, considering the significant roles MYC holds in cancer development, the present study discusses effective direct or
indirect therapeutic strategies to combat MYC-driven cancer progression.
 
        บทความปริทรรศน์ฉบับนี้กล่าวถึง Myc ที่มีบทบาทหลากหลายในการควบคุมทั้งกระบวนการที่เกี่ยวกับเมตาบอลิสมและภูมิคุ้มกันของมะเร็ง และความสัมพันธ์ของทั้งสองกระบวนการ ตลอดจนกลยุทธที่อาจใช้ยับยั้งมะเร็งชนิดที่เกิดจากการกระตุ้น Myc

Reference

Venkatraman S, Balasubramanian B, Thuwajit C, Meller J, Tohtong R, Chutipongtanate S. Targeting MYC at the intersection between cancer metabolism and oncoimmunology. Front Immunol. 2024 Feb 8;15:1324045.

DOI: 10.3389/fimmu.2024.1324045.