Pyruvate carboxylase (PC) (EC 6.4.1.1) is a biotin-dependent carboxylase which catalyzes the ATP-dependent carboxylation of pyruvate to form oxaloacetate which is an important precursor
Month: January 2022
Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
The tricarboxylic acid (TCA) cycle functions as both an oxidative hub to oxidize acetyl-CoA and a biosynthetic hub for the synthesis of nucleotides,
Five-(Tetradecyloxy)-2-furoic Acid Alleviates Cholangiocarcinoma Growth by Inhibition of Cell-cycle Progression and Induction of Apoptosis
Metabolic reprograming in cancers is one of cancer hallmarks that allow cancer cell to expand and metastasize to other organs. In collaboration with Assoc Prof
Pyruvate carboxylase supports basal ATP-linked respiration in human pluripotent stem cell-derived brown adipocytes
Brown adipose tissue or BAT is the adipocytes that have a specific physiology in maintaining body temperature via thermogenesis. BAT activity is mainly
Differential growth inhibition, cell cycle arrest and apoptosis of MCF-7 and MDA-MB-231 cells to holocarboxylase synthetase suppression
Metabolic reprograming in cancers is one of cancer hallmarks that allow cancer cell to expand and metastasize to other organs. Professor Sarawut
Baicalein Inhibits Metastatic Phenotypes in Nasopharyngeal Carcinoma Cells via a Focal Adhesion Protein Integrin β8
Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. Here
Frontiers in antibiotic alternatives for Clostridioides difficile infection
Clostridioides difficile is considered a threat to public health owing to increases in treatment failure over the past few years. Current antibiotic treatment options are
Teicoplanin Suppresses Vegetative Clostridioides difficile and Spore Outgrowth
Clostridioides difficile, previously known as Clostridium difficile, infection (CDI) accounts for about 20–25% of antibiotic associated diarrhea. It is classified as a pathogen posing an
Integrin α5 mediates intrinsic cisplatin resistance in three-dimensional nasopharyngeal carcinoma spheroids via the inhibition of phosphorylated ERK /caspase-3 induced apoptosis
Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. One
Large-scale comparative transcriptomic analysis of temperature-responsive genes in Arabidopsis thaliana
Large-scale comparative transcriptomic analysis of temperature-responsive genes in Arabidopsis thaliana Dr. Charoensawan and his PhD student, Ms Sriden have gathered and re-analyzed