Holocarboxylase synthetase (HLCS) is the enzyme that regulates biotin carboxylase activities, and plays an important role in cancer metabolism. Here, we investigated the global biochemical
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BC Special Seminar: January 15, 2024
BC Special Seminar “Science Careers in Pharma Beyond the Bench” by Chatarin (Chad) Wangsanuwat, Ph.D. University of California, Santa Barbara Current position: Senior Scientist, Moderna
BC Special Seminar: January 24, 2024
BC Special Seminar “Science Careers in Pharma Beyond the Bench” by Dr. Oleg Lavrukhin Regional Field Medical Lead Sanofi US Time: 1:00-2:00 pm Venue:
BC Faculty Seminar: January 10, 2024
BC Faculty Seminar “Development of smart nano-delivery platforms targeting colorectal cancer for personalized medicine: A showcase of ZY-444 small molecule targeting pyruvate carboxylase.” by Prof. Sarawut
Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells
Cholangiocarcinoma (CCA), a bile duct cancer, is an aggressive cancer with poor prognosis. It is typically recognized by its dense extracellular matrix nature which associated
Proteomic Analysis and Molecular Dynamics Simulation of Riboflavin-Coated Superparamagnetic Iron Oxide Nanoparticles Reveal Human Serum-Derived Protein Coronas: Implications as Magnetic Resonance Imaging Contrast Agents
This work, protein coronas of bare, citrate-coated, and Rf-coated SPIONs formed with human serum (HS) were studied by proteomic analysis to identify and quantify the
Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase
Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of meningococcal diseases. In this study,
Mangiferin is a new potential antimalarial and anticancer drug for targeting serine hydroxymethyltransferase
Serine hydroxymethyltransferase (SHMT) is a key enzyme in the deoxythymidylate synthesis cycle, essential for pathogen proliferations, including malaria parasite. Therefore, SHMT is an attractive
Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage
Dimethyl sulfone monooxygenase catalyzes the oxidative cleavage of dimethyl sulfone (DMSO2) to produce methanesulfinate and formaldehyde. It is a two-component monooxygenase composed of a
The plasmid vectors, pBS2ndd and pBS3ndd, for versatile cloning with low background in Escherichia coli
This is another approach to reduce background colonies, or false positive clones that may be arisen from intact or self-ligated plasmid in molecular cloning. Two