In collaboration with Dr. Dean Thumkeo and his team, Charoensawan laboratory at Department of Biochemistry, Faculty of Science, has contributed its expertise in single-cell transcriptomic
Category: BC Research
for Research Highlights only
Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection
Endolysin is a peptidoglycan hydrolase encoded in a phage genome. The enzyme is attractive due to its potential use as antibacterial treatment. ABSTRACT Endolysin is
The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2
Understanding human neurogenesis is critical toward regenerative medicine for neurodegeneration. However, little is known how neural differentiation is regulated by DEAD box-containing RNA helicases,
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera
Next-generation COVID-19 vaccines are critical due to the ongoing evolution of SARS-CoV-2 virus and rapid waning duration of the neutralizing antibody response against current vaccines.
Comparative Proteomic Profiling of Cisplatin-resistant Nasopharyngeal Carcinoma Cell Lines: Novel Biomarkers for Improving Chemotherapy of NPC
Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. One
Detection of cellular metabolites by redox enzymatic cascades
The measurement of cellular metabolites is crucial for medical applications as specific biomarkers can serve as disease indicators, while the detection of microbial metabolites
QM/MM molecular modeling reveals mechanism insights into flavin peroxide formation in bacterial luciferase
Bacterial luciferase (Lux) catalyzes light-emitting reactions, and the enzyme has long been used as a sensitive detection tool in biomedical, food, and environmental applications.
Luciferin synthesis and pesticide detection by luminescence enzymatic cascades
This research reported a novel, efficient, and green method to use enzymatic cascades, including esterase for pesticide transformation, flavin monooxygenase (HadA) for dehalogenation, flavin
Catalytic and structural insights into a stereospecific and thermostable Class II aldolase HpaI from Acinetobacter baumannii
Aldolase catalyzes reversible C-C bond condensation and joining. Its reaction is useful in biochemical synthesis, participating in extending the carbon chain length of a
Enhanced Functional Properties of Three DNA Origami Nanostructures as Doxorubicin Carriers to Breast Cancer Cells
Our group demonstrated that DNA origami nanostructures with different structural designs exhibited different drug delivery functionalities. We investigated three nanostructures: Disc, Donut, and Sphere,