Understanding human neurogenesis is critical toward regenerative medicine for neurodegeneration. However, little is known how neural differentiation is regulated by DEAD box-containing RNA helicases,
Category: BC Research
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A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera
Next-generation COVID-19 vaccines are critical due to the ongoing evolution of SARS-CoV-2 virus and rapid waning duration of the neutralizing antibody response against current vaccines.
Comparative Proteomic Profiling of Cisplatin-resistant Nasopharyngeal Carcinoma Cell Lines: Novel Biomarkers for Improving Chemotherapy of NPC
Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. One
Detection of cellular metabolites by redox enzymatic cascades
The measurement of cellular metabolites is crucial for medical applications as specific biomarkers can serve as disease indicators, while the detection of microbial metabolites
QM/MM molecular modeling reveals mechanism insights into flavin peroxide formation in bacterial luciferase
Bacterial luciferase (Lux) catalyzes light-emitting reactions, and the enzyme has long been used as a sensitive detection tool in biomedical, food, and environmental applications.
Luciferin synthesis and pesticide detection by luminescence enzymatic cascades
This research reported a novel, efficient, and green method to use enzymatic cascades, including esterase for pesticide transformation, flavin monooxygenase (HadA) for dehalogenation, flavin
Catalytic and structural insights into a stereospecific and thermostable Class II aldolase HpaI from Acinetobacter baumannii
Aldolase catalyzes reversible C-C bond condensation and joining. Its reaction is useful in biochemical synthesis, participating in extending the carbon chain length of a
Enhanced Functional Properties of Three DNA Origami Nanostructures as Doxorubicin Carriers to Breast Cancer Cells
Our group demonstrated that DNA origami nanostructures with different structural designs exhibited different drug delivery functionalities. We investigated three nanostructures: Disc, Donut, and Sphere,
Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration
The endocannabinoid system has been postulated to help restrict cancer progression and maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid receptor (CB)
Riboflavin-citrate conjugate multicore SPIONs with enhanced magnetic responses and cellular uptake in breast cancer cells
This work, we developed a novel riboflavin (Rf) functionalized superparamagnetic iron oxide nanoparticles (SPIONs) that has been beneficial in the advancement of contrast agents and