This is another approach to reduce background colonies, or false positive clones that may be arisen from intact or self-ligated plasmid in molecular cloning. Two
Category: BC Research
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Three novel mutations in α-galactosidase gene involving in galactomannan degradation in endosperm of curd coconut
This is the first report to identify gene in coconut responsible for curd phenotype. The gene is endosperm specific α-galactosidase. DNA encoding α-galactosidase gene alleles
Development and Validation of an Enzymatic Method to Determine Stevioside Content from Stevia rebaudiana
We established enzymatic method for specific determination of stevioside content. The key enzyme came from recombinant β-glucosidase BT_3567 (rBT_3567) from Bacteroides thetaiotaomicron HB-13 which exhibited
Proteomic analysis reveals distinct protein corona compositions of citrate- and riboflavin- coated SPIONs
This work, we reported the protein corona analysis of citrate- and riboflavin- coated superpartamagnetic iron oxide nanoparticles. Both are widely used as surface coating and
Molecularly Guided Drug Repurposing for Cholangiocarcinoma: An Integrative Bioinformatic Approach
Cholangiocarcinoma (CCA) has a complex immune microenvironment architecture, thus possessing challenges in its characterization and treatment. This study aimed to repurpose FDA-approved drugs for
In Silico Target Identification of Galangin, as an Herbal Flavonoid against Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a heterogenous group of malignancies in the bile duct which proliferates aggressively. As a result, most patients are diagnosed in advanced
Druggable Allosteric Sites in β-Propeller Lectins
β-Propeller lectins are a group of carbohydrate binding proteins consisting of repetitive protomers arranged in a propeller configuration. These lectins emerged as new targets for
Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA
LecA is a carbohydrate-binding protein released by an opportunistic bacterium Pseudomonas aeruginosa, as part of a myriad of virulence factors and thus, a prime therapeutic
Targeting undruggable carbohydrate recognition sites through focused fragment library design
Carbohydrate binding proteins are therapeutic targets because of their key role in host-pathogen recognition and cell-to-cell communication. Unfortunately, the hydrophilic nature of the carbohydrate binding
PGE 2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
In collaboration with Dr. Dean Thumkeo and his team, Charoensawan laboratory at Department of Biochemistry, Faculty of Science, has contributed its expertise in single-cell transcriptomic