Genome-Wide Transcriptional Regulation of the Long Non-coding RNA Steroid Receptor RNA Activator in Human Erythroblasts

Waritta Sawaengdee, Kairong Cui, Keji Zhao, Suradej Hongeng, Suthat Fucharoen

 and Patompon Wongtrakoongate

We report a novel function of the lncRNA SRA in regulation of global gene expression through direct chromatin binding in human erythroleukemia cell line K562 and in primary human proerythroblasts derived from HSCs. We demonstrate that SRA, together with CTCF, H3K4me3, and H3K27me3, occupies various genomic regions in K562. Further, SRA facilitates transcriptome-wide expression of erythroid program and expression of erythroid markers in K562 and in primary human proerythroblasts. Hence, a possible function of the lncRNA SRA is to promote transcription of erythroid associated genes.

Reference:

Sawaengdee W, Cui K, Zhao K, Hongeng S, Fucharoen S, Wongtrakoongate P. Genome-Wide Transcriptional Regulation of the Long Non-coding RNA Steroid Receptor RNA Activator in Human Erythroblasts. Front Genet. 2020 Aug 11;11:850. doi: 10.3389/fgene.2020.00850. eCollection 2020.

DOI: https://doi.org/10.3389/fgene.2020.00850