One of the major complications in diabetes mellitus is defect in wound repair process. Several evidences indicated that overproduction of reactive oxygen species (ROS) induced by high glucose impairs angiogenesis, thereby compromising wound repair process. Here we used endothelial cell, the cell lining blood vessel, as a model to investigate the effect of porcine placenta extract (PPE) on restoring angiogenesis impaired by high glucose media. This work indicated that PPE attenuates HG-induced intracellular ROS, leading to the improvement of EC viability, migration and angiogenesis and inhibition of ECs apoptosis, thus highlighting it as an alternative treatment for diabetic wound.
Nensat C, Songjang W, Tohtong R, Suthiphongchai T, Phimsen S, Rattanasinganchan P et al. Porcine placenta extract improves high glucose-induced angiogenesis impairment. BMC Complement Med Ther. 2021; 21:66. doi.org/10.1186/s12906-021-03243-z
|Assoc. Prof. Rutaiwan Tohtong
|Assoc. Prof. Tuangporn Suthiphongchai