Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. Here we showed that the cisplatin treatment enrichedcancer stem-like cells (CSCs), one major cause for failure of NPC chemotherapeutic treatments. The Wnt/β-catenin signaling is accountable for rising of the cancer stem-like cell population in NPC. Therefore, monitoring the targeted Wnt/β-catenin signaling pathway could potentially prevent the development of CSCs and improve the treatment efficiency in NPC.
Sinnung S, Janvilisri T, Kiatwuthinon P. Reversal of cisplatin sensitization and abrogation of cisplatin-enriched cancer stem cells in 5-8F nasopharyngeal carcinoma cell line through a suppression of Wnt/β-catenin-signaling pathway. Mol Cell Biochem. 2021 Apr;476(4):1663-1672. doi: 10.1007/s11010-020-04045-6. Epub 2021 Jan 9. PMID: 33423190.
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