The 4-hydroxyphenylacetate (4-HPA) degradation pathway enables environmental and pathogenic microbes to assimilate aromatic compounds, yet several steps in Acinetobacter baumannii TH remain unclear. While enzymes
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Structure and reaction mechanisms of a two-component indole monooxygenase from Acinetobacter baumannii
This study investigates how two-component indole monooxygenase from Acinetobacter baumannii converts indole into 3-hydroxyindole. The enzyme system consists of two cooperating proteins: reductase supplies reduced
Enhancing plant growth using anaerobic co-digestate of pig manure, food waste, and coffee grounds
This study demonstrates the use of anaerobic co-digestate liquid (AcoDL) derived from pig manure inoculum, food waste, and spent coffee grounds (PMI/FW/SCG) as a sustainable
Mechanisms and applications of bacterial luciferase and its auxiliary enzymes
Bacterial luciferase (LuxAB) catalyzes the conversion of reduced flavin mononucleotide (FMNH2), oxygen, and a long-chain aldehyde to oxidized FMN, the corresponding
In Silico and In Vitro Potential of FDA-Approved Drugs for Antimalarial Drug Repurposing against Plasmodium Serine Hydroxymethyltransferases
English Serine hydroxymethyltransferase (SHMT) is a key enzyme in deoxythymidylate synthesis pathway. It has been identified as a promising target for drug combating
Structure and biochemical characterization of an extradiol 3,4-dihydroxyphenylacetate 2,3-dioxygenase from Acinetobacter baumannii
English In this study, we report the structure and biochemical characterization of 3,4-Dihydroxyphenylacetate (DHPA) 2,3-dioxygenase (EC 1.13.11.15) from Acinetobacter baumannii (AbDHPAO), which is
A high catalytic efficiency and chemotolerant formate dehydrogenase from Bacillus simplex
English Formate dehydrogenase (FDH) catalyzes the reversible bioconversion of formate and NAD+ to produce carbon dioxide and NADH. FDH is biotechnologically important because it
Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase
Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of meningococcal diseases. In this study,
Mangiferin is a new potential antimalarial and anticancer drug for targeting serine hydroxymethyltransferase
Serine hydroxymethyltransferase (SHMT) is a key enzyme in the deoxythymidylate synthesis cycle, essential for pathogen proliferations, including malaria parasite. Therefore, SHMT is an attractive
Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage
Dimethyl sulfone monooxygenase catalyzes the oxidative cleavage of dimethyl sulfone (DMSO2) to produce methanesulfinate and formaldehyde. It is a two-component monooxygenase composed of a