English Serine hydroxymethyltransferase (SHMT) is a key enzyme in deoxythymidylate synthesis pathway. It has been identified as a promising target for drug combating
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Structure and biochemical characterization of an extradiol 3,4-dihydroxyphenylacetate 2,3-dioxygenase from Acinetobacter baumannii
English In this study, we report the structure and biochemical characterization of 3,4-Dihydroxyphenylacetate (DHPA) 2,3-dioxygenase (EC 1.13.11.15) from Acinetobacter baumannii (AbDHPAO), which is
A high catalytic efficiency and chemotolerant formate dehydrogenase from Bacillus simplex
English Formate dehydrogenase (FDH) catalyzes the reversible bioconversion of formate and NAD+ to produce carbon dioxide and NADH. FDH is biotechnologically important because it
Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase
Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of meningococcal diseases. In this study,
Mangiferin is a new potential antimalarial and anticancer drug for targeting serine hydroxymethyltransferase
Serine hydroxymethyltransferase (SHMT) is a key enzyme in the deoxythymidylate synthesis cycle, essential for pathogen proliferations, including malaria parasite. Therefore, SHMT is an attractive
Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage
Dimethyl sulfone monooxygenase catalyzes the oxidative cleavage of dimethyl sulfone (DMSO2) to produce methanesulfinate and formaldehyde. It is a two-component monooxygenase composed of a
BC Faculty Seminar: August 9, 2023
BC Faculty Seminar “Dehydrogenases: Mechanism insight and its versatile applications” by Assoc. Prof. Ruchanok Tinikul Department of Biochemistry, Faculty of Science, Mahidol University Date: Wednesday,
Congratulations to Asst. Prof. Dr. Ruchanok Tinikul
Congratulations to Asst. Prof. Dr. Ruchanok Tinikul on being promoted to “Associate Professor”
Detection of cellular metabolites by redox enzymatic cascades
The measurement of cellular metabolites is crucial for medical applications as specific biomarkers can serve as disease indicators, while the detection of microbial metabolites
QM/MM molecular modeling reveals mechanism insights into flavin peroxide formation in bacterial luciferase
Bacterial luciferase (Lux) catalyzes light-emitting reactions, and the enzyme has long been used as a sensitive detection tool in biomedical, food, and environmental applications.