Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. One major contributor to the chemoresistance includes identification of biomarkers for cisplatin resistance. Here we performed comparative proteomic profiles of cisplatin-resistant (CDDP/NPC) cell lines. We found 92 differentially expressed proteins (DEPs) contributing to the resistance to cisplatin in NPC cells. Among them, CKB and FUBP1 were further validated at the translational level and demonstrated corresponding expression levels at both protein and gene levels. They can potentially be used as a target candidate for the prognosis of drug resistance in NPC and targeted therapy.
Prathaphan P, Reamtong O, Ngaokrajang U, Janvilisri T, Swainson NM, Kiatwuthinon P. Comparative Proteomic Profiling of Cisplatin-resistant Nasopharyngeal Carcinoma Cell Lines: Novel Biomarkers for Improving Chemotherapy of NPC. Anticancer Res. 2022 Jul;42(7):3507-3522. doi: 10.21873/anticanres.15837. PMID: 35790268.
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