β-Propeller lectins are a group of carbohydrate binding proteins consisting of repetitive protomers arranged in a propeller configuration. These lectins emerged as new targets for
Month: July 2022
Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA
LecA is a carbohydrate-binding protein released by an opportunistic bacterium Pseudomonas aeruginosa, as part of a myriad of virulence factors and thus, a prime therapeutic
Targeting undruggable carbohydrate recognition sites through focused fragment library design
Carbohydrate binding proteins are therapeutic targets because of their key role in host-pathogen recognition and cell-to-cell communication. Unfortunately, the hydrophilic nature of the carbohydrate binding
BC Special Seminar: August 3, 2022
BC Special Seminar “Molecular Pharmacology for targeted cancer therapy: novel lead compounds targeting cancer cell signals” by Professor Dr. Pithi Chanvorachote Department of Pharmacology and
PGE 2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
In collaboration with Dr. Dean Thumkeo and his team, Charoensawan laboratory at Department of Biochemistry, Faculty of Science, has contributed its expertise in single-cell transcriptomic
Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection
Endolysin is a peptidoglycan hydrolase encoded in a phage genome. The enzyme is attractive due to its potential use as antibacterial treatment. ABSTRACT Endolysin is
The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2
Understanding human neurogenesis is critical toward regenerative medicine for neurodegeneration. However, little is known how neural differentiation is regulated by DEAD box-containing RNA helicases,
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera
Next-generation COVID-19 vaccines are critical due to the ongoing evolution of SARS-CoV-2 virus and rapid waning duration of the neutralizing antibody response against current vaccines.
Comparative Proteomic Profiling of Cisplatin-resistant Nasopharyngeal Carcinoma Cell Lines: Novel Biomarkers for Improving Chemotherapy of NPC
Nasopharyngeal carcinoma (NPC) originates from the epithelial cells of the nasopharynx. A high incidence is found in China and the Southeast Asia including Thailand. One