Cholangiocarcinoma (CCA) is a rare but highly lethal cancer arising from biliary tract. Its incidence is highest in Northeast, Thailand (about 100 times higher than in western countries), making it a serious public health problem in the Read More …
Cholangiocarcinoma (CCA) has a complex immune microenvironment architecture, thus possessing challenges in its characterization and treatment. This study aimed to repurpose FDA-approved drugs for cholangiocarcinoma by transcriptomic-driven bioinformatic approach. We derived an immune-oncogenic signature consisting of 26 Read More …
Cholangiocarcinoma (CCA) is a cancer of the bile duct with no effective therapy. This study explores the potential of inducing ‘apoptosis’ and ‘necroptosis’, a form of cell death, as a new effective therapeutic strategy for the treatment Read More …
Cholangiocarcinoma (CCA) originates from the biliary tract. CCA is associated with a high mortality rate and a concerning increase in incidence. Tumour heterogeneity complicates treatment therefore stratifying patients based on their molecular signature and biomarker-guided therapy may Read More …
The study of immune evasion has gained a well-deserved eminence in cancer research due to the development of immune checkpoint inhibitors, such as pembrolizumab and nivolumab. However, not all patients benefit from anti-PD-L1 or anti-CTLA4 treatment due Read More …
Cholangiocarcinoma (CCA) originates from the biliary tract. CCA is associated with a high mortality rate and a concerning increase in incidence. Here we show that for effective management of CCA, targeted therapy for precision medicine must be used Read More …
Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and currently there is no effective therapy for this disease. This study demonstrates that induction of necroptosis, a form of cell death, by using a smac mimetic, Read More …
BC Faculty Seminar “Therapeutic Potential of Ceritinib in Cholangiocarcinoma” by Prof. Rutaiwan Tohtong Department of Biochemistry, Faculty of Science, Mahidol University Join WebEx Meeting https://mahidol.webex.com/mahidol/j.php?MTID=m1c1dfe36aa68e5f8df5c9736d4f2d721 Meeting number: 2642 451 3662 Password: oct2021
One of the major complications in diabetes mellitus is defect in wound repair process. Several evidences indicated that overproduction of reactive oxygen species (ROS) induced by high glucose impairs angiogenesis, thereby compromising wound repair process. Here we used endothelial cell, Read More …
Bile duct cancer is among the top ten life-threatening cancers in Thailand. Currently, there is accumulating mass of microRNA (miRNA) profiling data, however, it is challenging to gain the maximal information from these data. This work therefore integrates Read More …